George Jung (Johnny Depp) doesn't want to live like his father (Ray Liotta)--always short of money, and always berated by his mother. So, he sets off for California, to live on the beach. George finds he can make a living selling drugs. One day he learns he could make more money by shipping drugs across the country. So, he does. Needing a bigger supply of drugs, he goes to Columbia, finds his way to Medellin, and meets Pablo Escobar (Cliff Curtis). George stumbles into becoming the biggest trafficker of cocaine in the U.S.