Picking up where the first left off, the show's second season finds each character in a state of turmoil. Having lost her husband, Bree uses white wine as a tool for coping with her conniving son and psychopath suitor. Meanwhile Gabrielle ponders whether or not to have a baby, Lynette shakes up her marital dynamics by going back to work, and Susan attempts to move on from Mike. The season also adds several new characters to the mix, including new Wisteria Lane resident Betty Applewhite (Alfre Woodard). And as everybody knows, new neighbours bring new mysteries. What, for example, are those strange sounds coming from Betty's basement?
Secrets and truths unfold through the lives of female friends in one suburban neighborhood, after the mysterious suicide of a neighbor.