At University Hospital School of Medicine, a group of ambitious medical students are about to die... and live to describe the experience. Embarking on a daring and arrogant experiment, the five aim to push through the confines of life and touch the face of death. In their search for knowledge, however, the five discover the chilling consequences of daring to tamper with immortality.
Between the past and the future, sanity and madness, dreams and reality, lies the mystery of the Twelve Monkeys... The year is 2035 and human kind subsists in a desolate netherworld following the eradication of 99% of the Earth's population, a holocaust that makes the planet's surface uninhabitable and mankind's destiny uncertain. Cole (Bruce Willis), a reluctant volunteer, aided by Dr Kathryn Railly (Madeleine Stowe) have only two clues to solve the puzzle of the Twelve Monkeys which threatens to completely erase humanity from the planet.