Here is a lovely long weekend (leaving on a Friday returning on a Monday), to Rome from Manchester. It is from 6th-9th January, so just after Christmas, so forget getting your other half rubbish Christmas presents they won't use, and get a lovely city break instead!
The hotel is the beautiful Hotel Villa San Lorenza Maria, which has amazing reviews. The rate also includes breakfast and it is a short walk from the Termini Station, but also right next to a metro which is ideal for exploring Rome. You'll stay here for 3 nights.
I haven't included transfers but at the cheapest these can be 1.50Euro if you don't mind walking some distance from the airport to the train station, or there are a wide range of buses such as the Terravision buses which are around 4Euro pp each way which go straight to the station and you can walk to the hotel from there. Alternatively, taxis are available but they will obviously be more expensive.
3 nights in the Hotel Villa San Lorenza Maria £135.77 book at hotels.com
Flights bookable at Ryanair £87.96.