When their friend Cookie OD's, best buddies and musicians Spoon (Tupac Shakur) and Stretch (Tim Roth) decide it's time to kick their drug habit by putting themselves into detox. But they soon discover that the road to rehab is paved with reams of social service red tape.
Spoon and Stretch are just trying to stay alive until they can get treatment. But, between the angry drug dealers, the cops who have mistaken them for murderers, and the people with forms and clipboards, this turns into a task of epic proportions. Thus enfolds their comic adventure to sobriety.