Takes place in 2029, 2 years after Human Revolution.
Jensen is part of a covert, goverment-sponsored task force called Task Force 29, a new bracnh of Interpol, to combat a new breed of terrorism. In true Deus Ex fashion, you often receive conflicting missions, neither can be fully trusted.
Boss encounters are designed in a way to allow players to approach any way they want (stealth, full combat, etc). "You can go full combat or full stealth throughout any part of the game".
Side quests meant to be more meaningful; ex.