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Awakening from a drugged stupor, Dr. Lawrence Gordon (Cary Elwes) finds himself chained to a pipe in a dingy bathroom, with another man (Leigh Whannell) in the same situation across the room . The men are the latest victims of the Jigsaw Killer, a maniac who uses elaborate traps to test his victims' dedication to life. Given six hours, a hacksaw, and a bullet, Dr. Gordon tries to figure out a way to freedom, hoping his kidnapped family (including Monica Potter) can survive the nightmare as well. Hot on the Jigsaw's trail is Detective David Tapp (Danny Glover), an equally as insane cop who was once the victim of the Jigsaw's evil scheme.
Jigsaw is back. The brilliant, disturbed mastermind who wreaked havoc on his victims in last year's SAW is back for another round of horrifying life-or-death games. When a new murder victim is discovered with all the signs of Jigsaw's hand, Detective Eric Mathews (Donnie Wahlberg) begins a full investigation and apprehends Jigsaw with little effort. But for Jigsaw, getting caught is just another part of his nefarious plan. Eight more of his victims are already fighting for their lives - and now it's time for Mathews to join the game...
Jigsaw has disappeared. Along with his new apprentice Amanda (Shawnee Smith), the puppet-master behind the cruel, intricate games that have terrified a community and baffled police has once again eluded capture and vanished.
While city detectives scramble to locate him, Doctor Lynn Denlan (Bahar Soomekh) and Jeff Reinhart (Angus Macfadyen) are unaware that they are about to become the latest pawns on his vicious chessboard.
Upon the news of Detective Kerry's murder, two seasoned FBI profilers, Agent Strahm and agent Perez, arrive at the depleted police precinct and help veteran Detective Hoffman sift through Jigsaw's latest grizzly game of victims and piece together the puzzle. But then SWAT Commander Rigg, the only local officer who has yet to experience Jigsaw's handiwork, is suddenly abducted. Thrust into the madman's harrowing game, he has but ninety minutes to overcome a diabolical series of interconnected traps ... or face the deadly consequences.
Rigg's citywide pursuit leaves a wake of dead bodies, and Detective Hoffman and the FBI uncover long hidden clues that lead them back to Jigsaw's ex-wife Jill. The genesis of Jigsaw's evil is unveiled, exposing the puppet master's true intentions and the sinister plan for his past, present and future victims.