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Jonathan Demme directed this genre-bending thriller in which Jodie Foster portrays Clarice Starling, an ambitious FBI student who is on the verge of graduation when her superior enlists her help to track down a serial killer. When a senator's daughter turns up missing, the feds determine the most likely suspect is Buffalo Bill, who is murdering women and doing something terrible with their skin. But to find him, Starling is forced to enlist the aid of another notorious serial killer--the terminally incarcerated ex-psychiatrist known as Hannibal the Cannibal Lecter (Anthony Hopkins). Hannibal is the only one who truly understands the killer's mind and motive. He agrees to help Clarice, but in exchange, she has to tell him her deepest secrets. Slowly she wins Hannibal over as he discovers that unlike most heroes, she is more moved by vulnerability than she is attracted to power. Clarice's relentless search for the killer and Hannibal's unorthodox analysis are chilling. The screenplay is based on the best-selling novel by Thomas Harris.