Frank Martin (Jason Statham) has been pressured into transporting a package, together with Valentina (Natalya Rudakova), the kidnapped daughter of Leonid Vasilev (Jeroen Krabbe); as it turns out later, the objective is to deliver her. Both have a device attached to their wrist which will explode if the person concerned goes more than 75 feet from the car. Vasilev is the head of the Environmental Protection Agency for Ukraine. Frank Martin must travel from Marseille through Munich and Budapest until he ends up in Odessa on the Black Sea. With the help of Inspector Tarconi (Fran?s Berl?d), Frank must contend with the people who strong-armed him into taking the job, agents sent by the Ukrainian government to intercept him, and the general non-cooperation of his passenger.
Valentina thinks she is going to die, and consumes drugs and alcohol to feel better and have some fun for the last time. Frank is not happy with this, because both have to remain sharp. However, Frank and Valentina fall for each other, while escaping from one life-threatening situation after another.